Tissue engineered hydrogels supporting 3D neural networks
نویسندگان
چکیده
منابع مشابه
Engineered Polymeric Hydrogels for 3D Tissue Models
Polymeric biomaterials are widely used in a wide range of biomedical applications due to their unique properties, such as biocompatibility, multi-tunability and easy fabrication. Specifically, polymeric hydrogel materials are extensively utilized as therapeutic implants and therapeutic vehicles for tissue regeneration and drug delivery systems. Recently, hydrogels have been developed as artific...
متن کاملEngineered 3D Silk-collagen-based Model of Polarized Neural Tissue
Despite huge efforts to decipher the anatomy, composition and function of the brain, it remains the least understood organ of the human body. To gain a deeper comprehension of the neural system scientists aim to simplistically reconstruct the tissue by assembling it in vitro from basic building blocks using a tissue engineering approach. Our group developed a tissue-engineered silk and collagen...
متن کاملRebuilding Brain Circuitry with Living Micro-Tissue Engineered Neural Networks.
Prominent neuropathology following trauma, stroke, and various neurodegenerative diseases includes neuronal degeneration as well as loss of long-distance axonal connections. While cell replacement and axonal pathfinding strategies are often explored independently, there is no strategy capable of simultaneously replacing lost neurons and re-establishing long-distance axonal connections in the ce...
متن کاملTunable Collagen I Hydrogels for Engineered Physiological Tissue Micro-Environments
Collagen I hydrogels are commonly used to mimic the extracellular matrix (ECM) for tissue engineering applications. However, the ability to design collagen I hydrogels similar to the properties of physiological tissues has been elusive. This is primarily due to the lack of quantitative correlations between multiple fabrication parameters and resulting material properties. This study aims to ena...
متن کاملBioactive Thermoresponsive Hydrogels for Neural Tissue Engineering
Traumatic injury to the central nervous system triggers cell death and deafferentation, which may activate a cascade of cellular and network disturbances. These events often result in the formation of irregularly shaped lesions comprised of necrotic tissue and/or a fluid-filled cavity. Tissue engineering represents a promising treatment strategy for the injured neural tissue. To facilitate mini...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Biomaterialia
سال: 2019
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2018.11.044